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Minireview: invasive fungal infection complicating acute Plasmodium falciparum malaria

Identifieur interne : 001539 ( Main/Exploration ); précédent : 001538; suivant : 001540

Minireview: invasive fungal infection complicating acute Plasmodium falciparum malaria

Auteurs : Jan D Britz [Allemagne] ; Markward Schneider ; Gudrun Just-Nuebling [Allemagne] ; Andreas H. Groll [Allemagne]

Source :

RBID : ISTEX:2280F2505C9589C89DC5AEB704C47BEC90A1F3D7

English descriptors

Abstract

Malaria is the most important parasitic infection in people, affecting 5–10% of the world’s population with more than two million deaths a year. Whereas invasive bacterial infections are not uncommon during severe Plasmodium falciparum malaria, only a few cases of opportunistic fungal infections have been reported. Here, we present a fatal case of disseminated hyalohyphomycosis associated with acute P. falciparum malaria in a non‐immune traveller, review the cases reported in the literature and discuss the theoretical foundations for the increased susceptibility of non‐immune individuals with severe P. falciparum malaria to opportunistic fungal infections. Apart from the availability of free iron as sequelae of massive haemolysis, tissue damage, acidosis and measures of advanced life support, patients with complicated P. falciparum malaria also are profoundly immunosuppressed by the organism’s interaction with innate and adaptive host immune mechanisms.

Url:
DOI: 10.1111/j.1439-0507.2009.01826.x


Affiliations:


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Le document en format XML

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